# Case report: Clinical features and management outcomes of isolated corneal intraepithelial neoplasia

## TL;DR

This case report describes the clinical features and treatment outcomes of three rare cases of isolated corneal intraepithelial neoplasia using surgical and medical therapies.

## Contribution

The study provides new insights into the management outcomes of isolated corneal intraepithelial neoplasia through combined surgical and medical treatments.

## Key findings

- Case 1 showed no recurrence after 10 years of treatment with alcohol-assisted epitheliectomy and topical mitomycin C.
- Case 2 experienced lesion recurrence 2.5 years after treatment with excision and interferon injections.
- Case 3 had no recurrence at 6 months following excision and 5-fluorouracil treatment.

## Abstract

To report clinical features and treatment outcome of three cases with isolated corneal intraepithelial neoplasia (CIN).

This case series presents 3 patients with isolated CIN. Data collected included, presenting signs and symptoms including vision, anterior segment examination, medical and surgical outcomes and signs and symptoms at lost post-treatment visit.

Case 1 was a 45-year-old male who presented with an isolated grayish amoeboid corneal lesion which was excised with alcohol assisted epitheliectomy, he also received 6 cycles of topical mitomycin C (MMC) 0.02% and one injection of interferon alfa-2b with no recurrence during the 10-year follow-up period. Case 2 was 78-year-old male referred for a suspicious white corneal lesion which was completely excised, the patient also received 6 subconjunctival injections of interferon alpha-2b. However, the lesion recurred at 2.5-years post-treatment. Case 3 was a 63-year-old male patient who presented with an isolated corneal lesion that was excised using alcohol-assisted epitheliectomy, patient received four cycles of topical 5-fluorouracil with no recurrence at last follow-up visit at 6 months.

Isolated corneal intraepithelial neoplasia (CIN) is a rare entity with few reported cases in the literature. In this case series, we report long and short-term management outcomes of combined surgical and medical therapy for isolated CIN.