# Case Report: Successful treatment of external beam radiation-induced optic papillopathy with intravitreal anti-VEGF

**Authors:** Andrew R. Carey

PMC · DOI: 10.3389/fopht.2023.1144241 · Frontiers in Ophthalmology · 2023-04-28

## TL;DR

This case report describes successful treatment of a rare eye condition caused by radiation therapy using anti-VEGF injections.

## Contribution

Presents novel treatment success with anti-VEGF for radiation-induced optic papillopathy.

## Key findings

- Three cases showed improvement with intravitreal anti-VEGF treatment.
- Optic disc edema was localized to the intra-ocular optic nerve.
- Proposed diagnostic criteria and treatment approach are discussed.

## Abstract

Three cases of optic disc edema arising from radiation optic neuropathy isolated to the intra-ocular optic nerve following external beam radiation for head and neck squamous cell carcinoma are presented. A literature review of the etiology, presentation, and treatment is included for discussion, along with proposed diagnostic criteria.

## Linked entities

- **Diseases:** head and neck squamous cell carcinoma (MONDO:0010150)

## Full-text entities

- **Genes:** VEGFA (vascular endothelial growth factor A) [NCBI Gene 7422] {aka L-VEGF, MVCD1, VEGF, VPF}
- **Diseases:** optic disc edema (MESH:D010211), head and neck squamous cell carcinoma (MESH:D000077195), optic papillopathy (MESH:D009901)

## Full text

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## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11182080/full.md

## References

19 references — full list in the complete paper: https://tomesphere.com/paper/PMC11182080/full.md

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Source: https://tomesphere.com/paper/PMC11182080