Indolent T-cell Lymphoproliferative Disorder of the Gastrointestinal Tract Mimicking Crohn’s Disease

TL;DR

A rare T-cell lymphoproliferative disorder in the gut was mistaken for Crohn's disease, emphasizing the need for accurate diagnosis and new treatment approaches.

Contribution

A case of iCTLD-GI/iTLP-GI mimicking Crohn’s disease is reported with unique morphological features and potential therapeutic targets.

Findings

The patient exhibited Crohn’s disease-like morphological changes, previously unreported in iCTLD-GI/iTLP-GI.

Molecular studies identified potential therapeutic targets for managing iCTLD-GI/iTLP-GI.

Accurate diagnosis is crucial to avoid mismanagement as iCTLD-GI/iTLP-GI can closely resemble IBD.

Abstract

Indolent clonal T-cell lymphoproliferative disorder (iCTLD-GI)/indolent T-cell lymphoma of the gastrointestinal tract (iTLP-GI) poses diagnostic challenges, and despite its rarity, accurate diagnosis is crucial for appropriate management. We report the case of 34-year-old female with a 19-year history of gastrointestinal symptoms suggestive of inflammatory bowel disease (IBD). Subsequent evaluation revealed iCTLD-GI/iTLP-GI with extensive Crohn's disease-like morphological alterations, previously unreported. These macroscopic and microscopic aspects underscore the need for a comprehensive evaluation to avoid misdiagnosis with IBD. Additionally, molecular studies have identified potential therapeutic targets, highlighting the evolving management strategies. This case underscores the diagnostic complexity of iCTLD-GI/iTLP-GI, especially when the condition mimicks IBD such as Crohn's disease.

Figures