# Manganese-derived biomaterials for tumor diagnosis and therapy

## TL;DR

This review explores how manganese-based materials can be used for diagnosing and treating tumors, highlighting their versatility and potential in biomedical applications.

## Contribution

The paper provides a comprehensive review of Mn-derived biomaterials specifically for tumor diagnosis and therapy, an area previously lacking systematic analysis.

## Key findings

- Manganese-based materials show promise in various imaging techniques for tumor diagnostics.
- They offer multiple therapeutic approaches, including drug delivery and immunotherapy.
- The review outlines future directions for advancing Mn-based tumor treatments.

## Abstract

Manganese (Mn) is widely recognized owing to its low cost, non-toxic nature, and versatile oxidation states, leading to the emergence of various Mn-based nanomaterials with applications across diverse fields, particularly in tumor diagnosis and therapy. Systematic reviews specifically addressing the tumor diagnosis and therapy aspects of Mn-derived biomaterials are lacking. This review comprehensively explores the physicochemical characteristics and synthesis methods of Mn-derived biomaterials, emphasizing their role in tumor diagnostics, including magnetic resonance imaging, photoacoustic and photothermal imaging, ultrasound imaging, multimodal imaging, and biodetection. Moreover, the advantages of Mn-based materials in tumor treatment applications are discussed, including drug delivery, tumor microenvironment regulation, synergistic photothermal, photodynamic, and chemodynamic therapies, tumor immunotherapy, and imaging-guided therapy. The review concludes by providing insights into the current landscape and future directions for Mn-driven advancements in the field, serving as a comprehensive resource for researchers and clinicians.