# Does metabolic control of the disease related with bone turnover markers in children with type 1 diabetes mellitus in Turkey?

## TL;DR

This study examines how metabolic control affects bone markers in children with type 1 diabetes in Turkey.

## Contribution

The study identifies a link between HbA1c levels and bone turnover markers in children with type 1 diabetes.

## Key findings

- Children with HbA1c <8% had lower oxidative stress and higher osteocalcin levels.
- There was a significant association between oxidative stress and P1NP levels regardless of HbA1c.
- Metabolic control (HbA1c) and oxidative stress influence bone turnover biomarkers in type 1 diabetes.

## Abstract

The aim was to evaluate the effect of metabolic control on bone biomarkers in children with type I diabetes.

The children were divided into two groups according to their glycated hemoglobin (HbA1c) (%) levels: a group with HbA1c levels < 8% (n = 16) and: a group with HbA1c levels > 8% (n = 18). The serum total oxidative status (TOS) (µmol/L), total antioxidant status (TAS) (mmol/L), alkaline phosphatase (ALP) (IU/L), osteocalcin (OC) (ng/ml), procollagen type-1-N-terminal peptide (P1NP) (ng/ml), and vitamin D (IU) levels and food consumption frequencies were determined.

When patients were classified according to HbA1c (%) levels, those with HbA1c levels < 8% were found to have lower TOS (µmol/L) values (8.7 ± 6.16, 9.5 ± 5.60) and higher serum OC (ng/mL) (24.2 ± 16.92, 22.0 ± 6.21) levels than those with HbA1c levels > 8% (p < 0.05). Regardless of the level of metabolic control, there was a statistically significant association between serum TOS (µmol/L) and P1NP (ng/ml) (p < 0.05) levels, with no group-specific relationship (HbA1c levels <%8 or HbA1c levels >%8).

HbA1c and serum TOS levels had an effect on bone turnover biomarkers in individuals with type I diabetes.