# Dominant negative effect as a novel mechanism of SPAST gene mutation in a large family with hereditary spastic paraplegia

**Authors:** Ke Deng, Haibo Ruan, Feifei Yu, Zhenle Pei, Congjian Xu, Shuo Zhang

PMC · DOI: 10.1016/j.gendis.2023.101152 · Genes & Diseases · 2023-10-27

## Full-text entities

- **Genes:** SPAST (spastin) [NCBI Gene 6683] {aka ADPSP, FSP2, SPG4}
- **Diseases:** hereditary spastic paraplegia (MESH:D015419)

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Source: https://tomesphere.com/paper/PMC11176630