# In Silico Assessment of Chemical Disinfectants on Surface Proteins Unveiled Dissimilarity in Antiviral Efficacy and Suitability towards Pathogenic Viruses

## TL;DR

This study uses computer modeling to assess how well disinfectants work against viral surface proteins, finding that rutin is both effective and eco-friendly.

## Contribution

The study introduces an eco-pharmaco-economic analysis to evaluate disinfectants' antiviral efficacy and environmental impact.

## Key findings

- Rutin showed strong antiviral binding with an LBE of −8.49 ± 0.92 kcal/mol across tested proteins.
- Rutin outperformed other disinfectants in eco-pharmaco-economic balance and affordability.
- Disinfectants varied significantly in their binding affinities to viral proteins (p < 0.005).

## Abstract

Viral pathogens pose a substantial threat to public health and necessitate the development of effective remediation and antiviral strategies. This short communication aimed to investigate the antiviral efficacy of disinfectants on the surface proteins of human pathogenic viruses. Using in silico modeling, the ligand-binding energies (LBEs) of selected disinfectants were predicted and combined with their environmental impacts and costs through an eco-pharmaco-economic analysis (EPEA). The results revealed that the binding affinities of chemical disinfectants to viral proteins varied significantly (p < 0.005). Rutin demonstrated promising broad-spectrum antiviral efficacy with an LBE of −8.49 ± 0.92 kcal/mol across all tested proteins. Additionally, rutin showed a superior eco-pharmaco-economic profile compared to the other chemicals, effectively balancing high antiviral effectiveness, moderate environmental impact, and affordability. These findings highlight rutin as a key phytochemical for use in remediating viral contaminants.