# Synthesis and Study of Building Blocks with Dibenzo[b,f]oxepine: Potential Microtubule Inhibitors

## TL;DR

This paper describes the synthesis of new dibenzo[b,f]oxepine compounds that may inhibit microtubules and can be controlled with light.

## Contribution

A concise method for constructing dibenzo[b,f]oxepine derivatives with potential microtubule inhibition and photoswitchable properties is introduced.

## Key findings

- A method for synthesizing dibenzo[b,f]oxepine derivatives with azo bonds was developed.
- E/Z isomerization of the derivatives can be controlled using visible-wavelength light.
- The compounds were analyzed using both experimental and theoretical methods.

## Abstract

The synthesis of biphenylmethoxydibenzo[b,f]oxepine or photoswitchable fluorinated dibenzo[b,f]oxepine derivatives with one or three azo bonds, potential microtubule inhibitors, is described. Our studies provide a concise method for constructing derivatives containing the dibenzo[b,f]oxepine skeleton. An analysis of products was run using experimental and theoretical methods. Next, we evaluated the E/Z isomerization of azo-dibenzo[b,f]oxepine derivatives, which could be photochemically controlled using visible-wavelength light.