# An analysis of risk factors for visceral disseminated varicella in children

## TL;DR

This study identifies risk factors for severe varicella in children, helping doctors recognize high-risk patients early for timely treatment.

## Contribution

The study identifies specific clinical indicators as independent risk factors for visceral disseminated varicella in children.

## Key findings

- Abdominal pain is a significant risk factor for visceral disseminated varicella.
- Delayed antiviral therapy increases the risk of visceral dissemination.
- Elevated C-reactive protein and alanine aminotransferase levels are associated with severe varicella.

## Abstract

Visceral disseminated varicella involves the internal organs, and complications such as encephalitis, hepatitis, and coagulation disorders threaten a patient's life. In this study, our aim is to analyze the risk factors for visceral disseminated varicella to enable the early identification of patients at a high risk of visceral disseminated varicella.

We reviewed the medical records of children hospitalized with varicella. The data covered demographics, clinical manifestations, auxiliary examinations, treatments, and outcomes. Logistic regression was used to analyze the risk factors.

A multivariate logistic regression analysis showed that abdominal pain [odds ratio (OR) 20.451, 95% CI 1.637–255.548], increased levels of C-reactive protein (OR 12.794, 95% CI 1.820–89.937), increased levels of alanine aminotransferase (OR 7.453, 95% CI 1.624–34.206), and the time between onset and antiviral therapy of more than 7 days (OR 12.451, 95% CI 1.569–98.810) were independent risk factors for visceral disseminated varicella.

Patients with varicella who have the abovementioned risk factors need to be monitored for the risk of developing visceral disseminated varicella, for which timely antiviral therapy is necessary.