# Live-Birth Incidence of Isolated D-Transposition of Great Arteries—The Shift in Trends Due to Early Diagnosis

## TL;DR

This study shows that early diagnosis of D-transposition of great arteries in Romania led to fewer live births and more pregnancy terminations.

## Contribution

The study highlights a significant shift in diagnostic timing and termination rates for D-transposition of great arteries over 15 years.

## Key findings

- The live-birth incidence of D-transposition of great arteries decreased over the study period.
- The median gestational age at diagnosis dropped from 29.3 weeks to 13.4 weeks.
- Termination rates for affected pregnancies rose from 14.28% to 75%.

## Abstract

This is a single tertiary population-based study conducted at a center in southwest Romania. We retrospectively compared data obtained in two periods: January 2008–December 2013 and January 2018–December 2023. The global incidence of the transposition of great arteries in terminated cases, in addition to those resulting in live-born pregnancies, remained almost constant. The live-birth incidence decreased. The median gestational age at diagnosis decreased from 29.3 gestational weeks (mean 25.4) to 13.4 weeks (mean 17.2). The second trimester and the overall detection rate in the prenatal period did not significantly change, but the increase was statistically significant in the first trimester. The proportion of terminated pregnancies in fetuses diagnosed with the transposition of great arteries significantly increased (14.28% to 75%, p = 0.019).