Catalysis-Based Fluorometric Method for Semiquantifying Trace Palladium in Sulfur-Containing Compounds and Ibuprofen

TL;DR

A new fluorometric method can detect trace amounts of palladium in sulfur-containing compounds and ibuprofen, with minimal interference from certain sulfur compounds.

Contribution

The study demonstrates that the fluorometric method is effective for trace palladium detection despite the presence of some sulfur compounds.

Findings

Thiourea interferes with the fluorometric method, but sulfide, thiol, and thiocarbamate do not.

The method successfully detects palladium bound to sulfur-based scavenger resin.

The fluorometric method outperforms ICP-MS for trace palladium detection in ibuprofen.

Abstract

Trace palladium in synthetic materials can be rapidly
and inexpensively
semiquantified by a catalysis-based fluorometric method that converts
resorufin allyl ether to resorufin. However, whether sulfur compounds
would interfere with this method has not been systematically studied.
Herein, we show that although thiourea in solution interferes with
quantification, sulfide, thiol, and thiocarbamate do not. The fluorometric
method can also detect palladium bound to sulfur-based scavenger resin
and outperform inductively coupled plasma mass spectrometry for detecting
trace palladium in ibuprofen.

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