# Unexpected Seizure Activity in the Setting of Lamotrigine Toxicity

**Authors:** Danielle Pitter, Samantha Hanley, Hesham Eisa, Yash Nene, Xiangping Zhou

PMC · DOI: 10.7759/cureus.60094 · Cureus · 2024-05-11

## TL;DR

A case report highlights seizures and encephalopathy caused by lamotrigine overdose, emphasizing the need for careful monitoring.

## Contribution

This case report adds to the understanding of lamotrigine toxicity by highlighting underreported clinical manifestations.

## Key findings

- Acute encephalopathy occurred following lamotrigine overdose.
- Seizures were observed as a manifestation of lamotrigine toxicity.
- The case emphasizes the importance of monitoring lamotrigine-treated patients.

## Abstract

Lamotrigine, a widely utilized broad-spectrum anticonvulsant, is commonly prescribed for epilepsy management and bipolar mood disorders. Despite its extensive clinical usage, instances of lamotrigine overdose are underreported. Here, we present a case involving acute encephalopathy and seizure onset following an intentional lamotrigine overdose. This case underscores the importance of recognizing the potential clinical manifestations of lamotrigine toxicity, such as encephalopathy and seizures, emphasizing the necessity for vigilant management of patients receiving this medication.

## Linked entities

- **Chemicals:** lamotrigine (PubChem CID 3878)
- **Diseases:** epilepsy (MONDO:0005027), encephalopathy (MONDO:0005560)

## Full-text entities

- **Diseases:** Toxicity (MESH:D064420), bipolar mood disorders (MESH:D001714), overdose (MESH:D062787), epilepsy (MESH:D004827), Seizure (MESH:D012640), encephalopathy (MESH:D001927)
- **Chemicals:** Lamotrigine (MESH:D000077213)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11164127/full.md

## References

13 references — full list in the complete paper: https://tomesphere.com/paper/PMC11164127/full.md

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Source: https://tomesphere.com/paper/PMC11164127