# Long COVID cognitive sequelae 6 months postinfection and beyond: a scoping review protocol

## TL;DR

This paper outlines a scoping review protocol to explore long-term cognitive effects of COVID-19 six months post-infection and beyond.

## Contribution

The study introduces a structured method to identify research gaps in long COVID cognitive sequelae and their relation to initial disease severity.

## Key findings

- A systematic search identified 1409 eligible studies up to December 2023.
- Descriptive analyses and evidence gap maps will be used to summarize findings.
- The review will inform targeted rehabilitation and healthcare interventions for long COVID patients.

## Abstract

The novel and expanding field of long COVID research has undergone diverse methodological approaches in recent years. This protocol lays out the methodological approach, which aims at identifying nuances in current research. It underscores the necessity for a more precise understanding of prolonged cognitive sequelae and their relation to initial disease severity. The findings will add valuable insights for the development of targeted rehabilitation, healthcare interventions and thereby aid patients, clinicians, policymakers and researchers. Our upcoming research is introduced here.

To map current research in the field, a scoping review will be conducted and documented in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Review Extension standards. A systematic search of scientific databases (PubMed, EMBASE), presented 1409 eligible results, published up to 21 December 2023. After removal of duplicates, 925 articles were extracted for screening. Two independent reviewers will screen for titles, abstracts and full texts, to extract data, which will then be organised using charting software. Data for various variables, that is, journal info, studied population demographics, study design, long COVID related data, cognitive outcomes and neuropsychological tests will be gathered. Descriptive analyses, evidence gap maps, heat map quantifications and narrative synthesis will be conducted for reporting of results.

This scoping review has been registered with the Open Science Framework (https://doi.org/10.17605/OSF.IO/JHFX6).

Ethical approval is not required, as the study does not involve human participants. The findings will be disseminated through a publication in a scientific journal and within the professional network.