# Shaping the olfactory map: cell type-specific activity patterns guide circuit formation

**Authors:** Ai Nakashima, Haruki Takeuchi

PMC · DOI: 10.3389/fncir.2024.1409680 · Frontiers in Neural Circuits · 2024-05-27

## TL;DR

This paper reviews how specific patterns of neural activity guide the formation of the olfactory map in the brain.

## Contribution

It highlights new insights into how cell type-specific activity patterns shape the olfactory glomerular map.

## Key findings

- Cell type-specific temporal patterns of spontaneous activity influence olfactory map formation.
- Traditional views on synchronous neuronal activity are being challenged by new evidence.
- Understanding spatiotemporal dynamics is key to studying complex neural circuit development.

## Abstract

The brain constructs spatially organized sensory maps to represent sensory information. The formation of sensory maps has traditionally been thought to depend on synchronous neuronal activity. However, recent evidence from the olfactory system suggests that cell type-specific temporal patterns of spontaneous activity play an instructive role in shaping the olfactory glomerular map. These findings challenge traditional views and highlight the importance of investigating the spatiotemporal dynamics of neural activity to understand the development of complex neural circuits. This review discusses the implications of new findings in the olfactory system and outlines future research directions.

## Full-text entities

- **Genes:** Kirrel3 (kirre like nephrin family adhesion molecule 3) [NCBI Gene 67703] {aka 1500010O20Rik, 2900036G11Rik, NEPH2, SST4, mKIAA1867}, Epha5 (Eph receptor A5) [NCBI Gene 13839] {aka Cek7, Ehk1, Els1, Hek7, Rek7, bsk}, Kcnj2 (potassium inwardly-rectifying channel, subfamily J, member 2) [NCBI Gene 16518] {aka IRK1, Kcnf1, Kir2.1}, Adcy3 (adenylate cyclase 3) [NCBI Gene 104111] {aka AC3, ACIII, mKIAA0511}, Epha1 (Eph receptor A1) [NCBI Gene 13835] {aka 5730453L17Rik, Eph, Esk}, Efna5 (ephrin A5) [NCBI Gene 13640] {aka AL-1, EFL-5, Ephrin-A5, Epl7, LERK-7, RAGS}, PCDH10 (protocadherin 10) [NCBI Gene 57575] {aka OL-PCDH}, Kirrel2 (kirre like nephrin family adhesion molecule 2) [NCBI Gene 243911] {aka C330019F22Rik, NEPH3, NLG1}, KIRREL2 (kirre like nephrin family adhesion molecule 2) [NCBI Gene 84063] {aka FILTRIN, NEPH3, NLG1}
- **Diseases:** OSN (MESH:D000857)
- **Chemicals:** calcium (MESH:D002118), cAMP (-)
- **Species:** Mus musculus (house mouse, species) [taxon 10090]

## Full text

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## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11163119/full.md

## References

60 references — full list in the complete paper: https://tomesphere.com/paper/PMC11163119/full.md

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Source: https://tomesphere.com/paper/PMC11163119