# Traumatic False Passage During Nasogastric Tube Insertion and Spontaneous Small Bowel Perforation in a Patient With Vascular Ehlers-Danlos Syndrome: A Case Report

**Authors:** Blanche Lee

PMC · DOI: 10.7759/cureus.60063 · Cureus · 2024-05-10

## TL;DR

This case report describes a rare complication of nasogastric tube insertion in a patient with vascular Ehlers-Danlos Syndrome, leading to a false passage and bowel perforation.

## Contribution

The report highlights an unusual clinical event in a patient with vascular EDS, emphasizing the risks of routine procedures in this fragile population.

## Key findings

- A patient with vascular EDS experienced spontaneous small bowel perforation during nasogastric tube insertion.
- A traumatic false passage was created in the parapharyngeal space during the procedure.
- This case underscores the increased tissue fragility in vascular EDS patients during medical interventions.

## Abstract

Ehlers-Danlos Syndrome (EDS) is a rare connective tissue disorder characterized by mutation in genes that encode or modify collagen. Clinical findings in these patients include skin hyperextensibility, hypermobility of joints, and tissue fragility. Vascular EDS (vEDS) is an autosomal dominant disease typically caused by a mutation in COL3A1, which encodes type III collagen. Presenting signs in the majority of vEDS patients include arterial rupture, uterine rupture, and sigmoid colon perforation. In this case report, the author presents an unusual case of spontaneous small bowel perforation and the creation of a traumatic false passage in the parapharyngeal space during a complicated nasogastric tube insertion in a patient with vEDS.

## Linked entities

- **Genes:** COL3A1 (collagen type III alpha 1 chain) [NCBI Gene 1281]
- **Diseases:** Ehlers-Danlos Syndrome (MONDO:0020066), vascular Ehlers-Danlos Syndrome (MONDO:0017314)

## Full-text entities

- **Genes:** COL3A1 (collagen type III alpha 1 chain) [NCBI Gene 1281] {aka EDS4A, EDSVASC, PMGEDSV}
- **Diseases:** tissue disorder (MESH:D017695), hypermobility of joints (MESH:D007593), arterial rupture (MESH:D012421), colon perforation (MESH:D015179), EDS (MESH:D004535), tissue fragility (MESH:D005600), Vascular EDS (MESH:D000094623), uterine rupture (MESH:D014597), autosomal dominant disease (MESH:D030342), skin hyperextensibility (MESH:D012871), Bowel Perforation (MESH:D057112)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

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## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11162970/full.md

## References

7 references — full list in the complete paper: https://tomesphere.com/paper/PMC11162970/full.md

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Source: https://tomesphere.com/paper/PMC11162970