# Disconnected Pancreatic Duct Syndrome: A Rare Complication of Pancreatitis

## TL;DR

A rare condition called disconnected pancreatic duct syndrome occurred in a patient with a less severe form of pancreatitis, highlighting the need for awareness in similar cases.

## Contribution

This is the first reported case of DPDS arising from acute non-necrotizing pancreatitis.

## Key findings

- DPDS was confirmed in a patient with acute non-necrotizing pancreatitis using imaging and lab tests.
- Endoscopic treatment with stent placement resolved the patient's symptoms and reduced fluid accumulation.
- The case suggests DPDS can occur in less severe pancreatitis forms, not just necrotizing cases.

## Abstract

Disconnected pancreatic duct syndrome (DPDS) is a rare complication of a common disease. Typically, DPDS occurs in acute necrotizing pancreatitis (ANP), chronic pancreatitis, abdominal surgery, or trauma. We present a case of DPDS from acute non-necrotizing pancreatitis (ANNP).

A 41-year-old male with a history of alcohol use and prior AP presented with progressive, severe left-sided abdominal pain that was worse with movement. Labs revealed a lipase of 95 U/L (normal range 11-82 U/L). Computed tomography (CT) of the abdomen/pelvis (A/P) with IV contrast demonstrated a large left-sided pleural effusion, non-necrotic pancreatic pseudocysts, and a large subdiaphragmatic fluid collection. Thoracentesis of the pleural effusion revealed an amylase of 601 U/L confirming pancreatic etiology. A subsequent magnetic resonance cholangiopancreatography (MRCP) confirmed complex peripancreatic ascites, rapid subdiaphragmatic fluid accumulation, and a fistula from the pancreatic tail to retroperitoneum concerning for a rapidly dissecting pancreatic pseudocyst. He ultimately underwent endoscopic retrograde cholangiopancreatography (ERCP) with stent placement in the main pancreatic duct. His left-sided abdominal pain rapidly improved, and the patient was discharged. CT A/P one week after discharge showed a reduced size of subdiaphragmatic fluid collection.

DPDS is usually seen in patients with a history of ANP. Our case demonstrates that it can also occur in ANNP, which has not previously been described in the literature. Therefore, a high index of clinical suspicion must be maintained for DPDS even in ANNP given its potential for severe complications.