# Validity of central pain processing biomarkers for predicting the occurrence of oncological chronic pain: a study protocol

## TL;DR

This study aims to identify biomarkers that can predict chronic cancer pain using AI, helping improve treatment decisions.

## Contribution

The novelty lies in using central pain processing biomarkers and AI to predict chronic cancer pain.

## Key findings

- A panel of biomarkers will be selected to predict chronic pain in cancer patients.
- AI algorithms will be used to develop a predictive tool for anticipating future pain.
- The study will clarify how treatment modality and patient factors influence pain development.

## Abstract

Despite recent improvements in cancer detection and survival rates, managing cancer-related pain remains a significant challenge. Compared to neuropathic and inflammatory pain conditions, cancer pain mechanisms are poorly understood, despite pain being one of the most feared symptoms by cancer patients and significantly impairing their quality of life, daily activities, and social interactions. The objective of this work was to select a panel of biomarkers of central pain processing and modulation and assess their ability to predict chronic pain in patients with cancer using predictive artificial intelligence (AI) algorithms.

We will perform a prospective longitudinal cohort, multicentric study involving 450 patients with a recent cancer diagnosis. These patients will undergo an in-person assessment at three different time points: pretreatment, 6 months, and 12 months after the first visit. All patients will be assessed through demographic and clinical questionnaires and self-report measures, quantitative sensory testing (QST), and electroencephalography (EEG) evaluations. We will select the variables that best predict the future occurrence of pain using a comprehensive approach that includes clinical, psychosocial, and neurophysiological variables.

This study aimed to provide evidence regarding the links between poor pain modulation mechanisms at precancer treatment in patients who will later develop chronic pain and to clarify the role of treatment modality (modulated by age, sex and type of cancer) on pain. As a final output, we expect to develop a predictive tool based on AI that can contribute to the anticipation of the future occurrence of pain and help in therapeutic decision making.