# Primary Neuroendocrine Tumor of the Testis Associated With Cardiac Symptoms: A Case Report and Literature Review

**Authors:** Eyad A Domlo, Furat A Almayouf, Shatha M Sulaiman, Abdulaziz A Alluhayb, Assem S Alrumeh

PMC · DOI: 10.7759/cureus.59955 · 2024-05-09

## TL;DR

A rare case of a testicular neuroendocrine tumor causing heart symptoms is reported, with histopathological confirmation.

## Contribution

Presentation of a rare case linking testicular neuroendocrine tumor with cardiac symptoms.

## Key findings

- A 47-year-old male presented with cardiac symptoms and a testicular mass.
- Histopathology confirmed a well-differentiated neuroendocrine tumor with positive synaptophysin and chromogranin A.
- The case highlights the rarity and unique clinical presentation of such tumors.

## Abstract

Well-differentiated neuroendocrine tumors of the testis are exceedingly rare. Here, we report the case of a 47-year-old male patient complaining of cardiac symptoms with a right testicular mass. A right radical orchiectomy was performed. The histopathological findings showed a well-differentiated neuroendocrine tumor with positive synaptophysin and chromogranin A immunostains.

## Linked entities

- **Diseases:** neuroendocrine tumor (MONDO:0019496)

## Full-text entities

- **Genes:** SYP (synaptophysin) [NCBI Gene 6855] {aka MRX96, MRXSYP, XLID96}, CHGA (chromogranin A) [NCBI Gene 1113] {aka CGA, PHE5, PHES}
- **Diseases:** testicular mass (MESH:D013733), Primary Neuroendocrine Tumor of the (MESH:D018358), Cardiac Symptoms (MESH:D006331)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11161907/full.md

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Source: https://tomesphere.com/paper/PMC11161907