# The Clinical and Histological Intersection of Cardiac Sarcoidosis and Giant Cell Myocarditis

**Authors:** Toishi Sharma, Kramer Wahlberg, Friederike Keating, Ahmed Harhash, Leslie T Cooper

PMC · DOI: 10.7759/cureus.59783 · 2024-05-07

## TL;DR

This paper presents a case where a heart condition showed features of both cardiac sarcoidosis and giant cell myocarditis, highlighting challenges in diagnosing and managing overlapping diseases.

## Contribution

The case demonstrates an intermediate clinicohistologic phenotype between cardiac sarcoidosis and giant cell myocarditis.

## Key findings

- The patient exhibited heart block and ventricular tachycardia.
- Cardiac MRI, FDG-PET, and biopsy revealed overlapping features of CS and GCM.
- The case highlights diagnostic and management challenges in overlapping cardiac conditions.

## Abstract

The clinical and imaging features of cardiac sarcoidosis (CS) and giant cell myocarditis (GCM) are occasionally indistinguishable. This is a case of heart block and ventricular tachycardia where cardiac MRI, fluorodeoxyglucose positron emission tomography (FDG-PET) and biopsy revealed intermediate clinicohistologic phenotype between CS and GCM. This highlights gaps in the management of overlap conditions.

## Linked entities

- **Diseases:** cardiac sarcoidosis (MONDO:0001707), giant cell myocarditis (MONDO:0023232), ventricular tachycardia (MONDO:0005477)

## Full-text entities

- **Diseases:** ventricular tachycardia (MESH:D017180), CS (MESH:D012507), GCM (MESH:D009205), heart block (MESH:D006327)
- **Chemicals:** FDG (MESH:D019788)

## Figures

4 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11154654/full.md

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Source: https://tomesphere.com/paper/PMC11154654