# Genetic Appraisal of RAAS-Associated SNPs: REN (rs16853055), AGT (rs3789678) and ACE (rs4305) in Preeclamptic Women Living with HIV Infection

## TL;DR

This review examines if specific genetic variations in the RAAS system are linked to hypertension in preeclamptic women with HIV.

## Contribution

The paper provides a focused review on the genetic associations of RAAS SNPs in preeclamptic women co-infected with HIV.

## Key findings

- The AGT-rs3789678 polymorphism is significantly linked to gestational hypertension.
- The ACE-rs4305 polymorphism shows no significant association with pregnancy-induced hypertension.
- Certain AGT alleles are more common in HIV-infected preeclamptic women compared to normotensive HIV-infected pregnant women.

## Abstract

The primary goal of this review article was to determine whether the three RAAS-associated SNPs, Renin-rs16853055, AGT-rs3789678 and ACE-rs4305 are genetically linked to the development of hypertension in preeclampsia. The secondary goal was to establish if there was a link between these SNPs and HIV infection.

There is a paucity of findings related to the aforementioned SNPs and preeclampsia. There are no recent findings on the rs16853055 renin polymorphism. The rs3789678 angiotensinogen polymorphism correlated significantly with gestational hypertension. The rs4305 ACE polymorphism showed no significant association with the development of pregnancy-induced hypertension.

There are conflicting findings when determining the relationship between ethnicity and the predisposition of preeclampsia and hypertension in relation to the discussed RAAS-associated SNPs. To date, the association between RAAS-associated SNPs and preeclamptic women co-morbid with HIV in South Africa has revealed that certain alleles of the AGT gene are more prominent in HIV-infected PE compared to normotensive pregnant HIV-infected women.