# The Development of IgE Multiple Myeloma Following Treatment for Locally Advanced Prostate Cancer

**Authors:** Motoki Fujita, Issei Suzuki, Tomoya Mizuno, Hiroyuki Kobayashi, Tsunehito Kambara

PMC · DOI: 10.7759/cureus.59732 · Cureus · 2024-05-06

## TL;DR

A 74-year-old man developed IgE multiple myeloma after treatment for prostate cancer, highlighting the need to consider this condition in patients with nonspecific symptoms.

## Contribution

This case report adds to the understanding of IgE multiple myeloma as a rare complication following prostate cancer treatment.

## Key findings

- IgE multiple myeloma was diagnosed in a patient with nonspecific symptoms after prostate cancer treatment.
- The case highlights the importance of considering MM in the differential diagnosis despite normal PSA levels.
- Prompt diagnosis of MM is critical to prevent complications like renal impairment.

## Abstract

This case report documents the diagnosis of multiple myeloma (MM) in a 74-year-old man following treatment for locally advanced prostate cancer. It is important to include MM in the differential diagnosis when the patient presents with nonspecific symptoms such as back pain, anemia, and renal impairment in the absence of a prominent increase in prostate-specific antigen (PSA). The present case was diagnosed as IgE MM with a poor prognosis. Prompt diagnosis and intervention of MM is necessary to avoid complications, including renal impairment.

## Linked entities

- **Proteins:** KLK3 (kallikrein related peptidase 3)
- **Diseases:** multiple myeloma (MONDO:0009693), prostate cancer (MONDO:0005159)

## Full-text entities

- **Genes:** KLK3 (kallikrein related peptidase 3) [NCBI Gene 354] {aka APS, KLK2A1, PSA, hK3}
- **Diseases:** back pain (MESH:D001416), IgE MM (MESH:D009101), anemia (MESH:D000740), Prostate Cancer (MESH:D011471), renal impairment (MESH:D007674)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Full text

_Full body text omitted from this summary view._ Fetch the complete paper as Markdown: https://tomesphere.com/paper/PMC11152359/full.md

## Figures

2 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11152359/full.md

## References

15 references — full list in the complete paper: https://tomesphere.com/paper/PMC11152359/full.md

---
Source: https://tomesphere.com/paper/PMC11152359