Coronary Flow Velocity Reserve Declines After Anthracycline Therapy in Breast Cancer Patients

Christopher Yu; Prajith Jeyaprakash; Koya Ozawa; Tomoko Negishi; Dhanusha Sabanathan; John Park; Jennifer Man; Anuradha Vasista; Faraz Pathan; Kazuaki Negishi

PMC · DOI:10.1016/j.cjco.2024.01.009·February 3, 2024

Coronary Flow Velocity Reserve Declines After Anthracycline Therapy in Breast Cancer Patients

Christopher Yu, Prajith Jeyaprakash, Koya Ozawa, Tomoko Negishi, Dhanusha Sabanathan, John Park, Jennifer Man, Anuradha Vasista, Faraz Pathan, Kazuaki Negishi

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TL;DR

This study shows that a common breast cancer treatment reduces coronary blood flow reserve, suggesting potential heart risks.

Contribution

The study is the first to show coronary flow changes in humans after anthracycline therapy for breast cancer.

Findings

01

CFVR significantly declined after anthracycline therapy in breast cancer patients.

02

This is the first prospective study to identify such coronary physiology changes in a cardio-oncology context.

Abstract

Anthracycline therapy (ANT) is associated with cancer therapy-related cardiac dysfunction. Coronary flow velocity reserve (CFVR) has shown prognostic utility in non-cancer cohorts, but no data have been obtained in a cardio-oncology setting. We investigated the acute effect of ANT on CFVR in breast cancer patients. A total of 12 female breast cancer patients undergoing ANT had pre- and post-ANT CFVR assessment. A significant decline in CFVR occurred (baseline: 2.66 ± 0.41 vs post-ANT: 2.47 ± 0.37, P = 0.016). This prospective study is the first to identify ANT-related coronary physiology changes in humans. Further studies are required to determine their clinical significance.

Linked entities

Genes, proteins, chemicals, diseases, species, mutations and cell lines named across the full text — each resolved to its canonical identifier and authoritative record.

Species1

Homo sapiens(human · species)

Chemicals1

Anthracycline

Diseases3

breast cancer cancer cardiac dysfunction

Figures3

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Taxonomy

TopicsCardiac Imaging and Diagnostics · Chemotherapy-induced cardiotoxicity and mitigation · Coronary Interventions and Diagnostics