Clinical course, treatment and management of generalised pustular psoriasis from a United Kingdom extension of a global Delphi panel

TL;DR

UK dermatologists agree on most aspects of managing generalised pustular psoriasis, aligning with global guidelines but noting some areas of disagreement.

Contribution

Validation of a global GPP management algorithm within the UK context and identification of areas requiring further consensus.

Findings

88% consensus on 89 out of 101 statements regarding GPP management.

Disagreement exists on age's prognostic value, QoL tools, and comorbidity nature.

UK panel confirmed alignment with global clinical algorithms for GPP.

Abstract

This article presents the results of the UK extension of a previously conducted global Delphi panel on generalised pustular psoriasis (GPP). Five UK based dermatologists experienced in GPP management have expressed their level of agreement on 101 questionnaire statements addressing four aspects of GPP: clinical course and flare definition, diagnosis, treatment goals, and holistic management. Consensus was achieved for 89 of 101 statements (88%). Disagreement was detected on issues around the prognostic value of age, QoL assessment tools and the nature of comorbidities associated with GPP. Overall, the panelists corroborated the results of the global study and confirmed that the clinical algorithm derived from the global study is in accordance with the UK clinical practice.

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