# Expression of Concern: Hydroxychavicol, a Piper betle leaf component, induces apoptosis of CML cells through mitochondrial reactive oxygen species‐dependent JNK and endothelial nitric oxide synthase activation and overrides imatinib resistance

PMC · DOI: 10.1111/cas.16155 · Cancer Science · 2024-03-27

## Full-text entities

- **Genes:** MAPK8 (mitogen-activated protein kinase 8) [NCBI Gene 5599] {aka JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8}
- **Diseases:** CML (MESH:D015464)
- **Chemicals:** imatinib (MESH:D000068877), Piper betle leaf (-), reactive oxygen species (MESH:D017382), Hydroxychavicol (MESH:C051268)

## Full text

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Source: https://tomesphere.com/paper/PMC11145107