Development of an Undifferentiated Pleomorphic Sarcoma After Aortic Aneurysm Graft Replacement: A Case Report and Literature Review

TL;DR

This case report describes the first known undifferentiated pleomorphic sarcoma that developed after aortic graft replacement, diagnosed through detailed postmortem analysis.

Contribution

The novelty lies in the first documented case of graft-associated undifferentiated pleomorphic sarcoma confirmed with comprehensive immunohistochemical and FISH analysis.

Findings

An 88-year-old man developed undifferentiated pleomorphic sarcoma after aortic graft replacement.

The diagnosis was confirmed postmortem using detailed immunohistochemical staining and FISH.

This case expands the understanding of rare graft-associated sarcomas beyond angiosarcomas and intimal sarcomas.

Abstract

Aortic sarcomas are extremely rare. Sarcomas associated with aortic graft replacement are even rarer; only 17 cases have been examined through immunohistochemical staining to date, most of which were either angiosarcomas or intimal sarcomas. Here, we report the case of an 88-year-old man with an undifferentiated pleomorphic sarcoma (UPS) that developed after aortic graft replacement and was diagnosed through postmortem autopsy. To the best of our knowledge, this is the first case of graft-associated sarcoma diagnosed as an undifferentiated pleomorphic type following detailed immunohistochemical staining with sufficient antibodies and fluorescencein situ hybridization (FISH).

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