A Case Report: Monoclonal Gammopathy of Undetermined Significance Presenting With Renal Amyloidosis and Reactive Thrombocytosis

TL;DR

This case report describes a rare presentation of MGUS with renal amyloidosis and thrombocytosis, highlighting the importance of early diagnosis to prevent organ damage.

Contribution

The novelty lies in presenting a rare clinical case of MGUS with thrombocytosis and renal amyloidosis, emphasizing diagnostic challenges.

Findings

A 63-year-old patient presented with MGUS, renal amyloidosis, and severe thrombocytosis.

The case highlights thrombocytosis as a rare initial manifestation of MGUS.

Timely diagnosis and intervention are crucial to prevent irreversible organ damage.

Abstract

Monoclonal gammopathy of undetermined significance (MGUS) is a pre-neoplastic condition involving plasma cells or lymphoplasmacytic proliferation-clinical presentations ranging from asymptomatic to symptoms of systematic organ involvement. It is commonly associated with light chain amyloidosis and usually strengthens during diagnosis. It is usually associated with thrombocytopenia in addition to anemia. This case report focuses on a 63-year-old Hispanic female who initially presented without any symptoms but with severe thrombocytosis. The finding of renal amyloidosis boosts the final diagnosis of MGUS. Rarely a patient is initially presented with severe thrombocytosis despite thrombocytopenia, which is commonly associated with plasma cell disorders. The case emphasizes the need for considering plasma cell disorders in patients with abnormal hematologic manifestations. It highlights the importance of timely identification and intervention to prevent irreversible organ damage by providing a detailed analysis of the clinical presentation and diagnostic evaluation.

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