# Perioperative Use of Levosimendan in Hepatic Transplantation With Diastolic Heart Failure: A Case Report

**Authors:** Erick Villafán Vázquez, Ricardo Acuña Razo, Mayra Michelle Nuñez Rueda

PMC · DOI: 10.7759/cureus.59490 · 2024-05-01

## TL;DR

This case report describes the use of levosimendan during liver transplantation in a patient with heart and lung issues.

## Contribution

The paper presents a novel case of levosimendan use in hepatic transplantation with diastolic heart failure.

## Key findings

- Levosimendan was used in a complex transplant case with diastolic heart failure and pulmonary hypertension.
- Current evidence on levosimendan's perioperative use remains insufficient for standardized guidelines.

## Abstract

Levosimendan is a medication with a range of pharmacological effects, making it appropriate for use in several clinical settings, including advanced heart failure with pulmonary hypertension, cardiogenic shock, and acute heart failure. This case report details the perioperative management of a male in their 40s with a complex medical history, including primary hypoparathyroidism, cirrhosis, and severe pulmonary hypertension, who underwent urgent cadaveric donor liver transplantation. Information available on the perioperative use of levosimendan is still insufficient to be able to regulate behaviors that can guide its management on a regular basis.

## Linked entities

- **Chemicals:** Levosimendan (PubChem CID 3033825)
- **Diseases:** cirrhosis (MONDO:0005155), pulmonary hypertension (MONDO:0005149), diastolic heart failure (MONDO:0006727)

## Full-text entities

- **Diseases:** Diastolic Heart Failure (MESH:D054144), cardiogenic shock (MESH:D012770), cirrhosis (MESH:D005355), heart failure (MESH:D006333), pulmonary hypertension (MESH:D006976), hypoparathyroidism (MESH:D007011)

## Figures

1 figure with captions in the complete paper: https://tomesphere.com/paper/PMC11144050/full.md

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Source: https://tomesphere.com/paper/PMC11144050