# Idelalisib-Induced Pneumonitis in Chronic Lymphocytic Leukemia

**Authors:** Sasikanth N Ravi, Irene W Choi, Eva K Ngapgue, Amanda G Stroiney, Clive J Miranda

PMC · DOI: 10.7759/cureus.59541 · 2024-05-02

## TL;DR

This paper discusses a case of lung inflammation caused by a drug used to treat chronic lymphocytic leukemia and emphasizes the need for early diagnosis and personalized treatment.

## Contribution

The paper presents a case report of idelalisib-induced pneumonitis and highlights the importance of early diagnosis and tailored treatment.

## Key findings

- Idelalisib, a PI3Kδ inhibitor, is effective in treating relapsed chronic lymphocytic leukemia.
- Idelalisib can cause pneumonitis, a serious side effect requiring early diagnosis and individualized treatment for better outcomes.

## Abstract

Idelalisib, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor, effectively treats relapsed chronic lymphocytic leukemia (CLL). While this targeted approach offers a therapeutic edge, particularly in B-cell malignancies, it is associated with complications such as pneumonitis. This report details idelalisib-induced pneumonitis, highlighting the importance of early diagnosis and tailored treatment in achieving a favorable patient outcome.

## Linked entities

- **Chemicals:** idelalisib (PubChem CID 11625818)
- **Diseases:** chronic lymphocytic leukemia (MONDO:0004948), pneumonitis (MONDO:0043905)

## Full-text entities

- **Genes:** PIK3CD (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta) [NCBI Gene 5293] {aka APDS, IMD14, IMD14A, IMD14B, P110DELTA, PI3K}
- **Diseases:** Pneumonitis (MESH:D011014), B-cell malignancies (MESH:D016393), CLL (MESH:D015451)
- **Species:** Homo sapiens (human, species) [taxon 9606]

## Figures

3 figures with captions in the complete paper: https://tomesphere.com/paper/PMC11144044/full.md

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Source: https://tomesphere.com/paper/PMC11144044