“Slight chemical damage due to drinking modest amount of sake, might induce beneficial effects” as a form of hormesis: an interview with Professor Sataro Goto

TL;DR

Professor Sataro Goto discusses how mild chemical damage from drinking sake may have beneficial effects on aging.

Contribution

The paper presents an interview with Professor Goto, highlighting his pioneering work on protein errors and aging.

Findings

Slight chemical damage from sake may induce hormesis, potentially benefiting aging.

Goto's research focuses on protein modifications and their role in aging and lifespan.

Dietary restriction and exercise are shown to modulate aging processes.

Abstract

Professor Sataro Goto is one of the pioneers of biological aging research in Japan. He is renowned for his work on the role of protein errors and modifications, the accumulation of abnormal proteins due to reduced protein turnover, and the modulation of aging and lifespan by adult-onset dietary restriction and regular exercise. Professor Goto is a remarkably intelligent, visionary, empathetic, humble, and wise man, who kindly agreed to this interview that I (Zsolt Radak) made with him during one of my frequent visits to his labs, in February 2023.

Figures