# Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese

## TL;DR

This study investigated whether genetic variations in IL10 and IL6R genes are linked to acute anterior uveitis in Han Chinese but found no significant associations.

## Contribution

The study is the first to explore IL10 and IL6R gene polymorphisms in acute anterior uveitis among Han Chinese.

## Key findings

- Ten SNPs in IL10 and IL6R genes were genotyped in 420 AAU patients and 918 controls.
- Four SNPs showed weak associations with AAU before correction, but none remained significant after Bonferroni correction.
- Haplotype analysis of the ten SNPs also revealed no association with AAU.

## Abstract

Several autoimmune disorders have been linked to polymorphisms in IL10 and IL6R genes. This research aimed to study whether single nucleotide polymorphisms (SNPs) in the genes of IL10 and IL6R were associated with acute anterior uveitis (AAU) in Han Chinese.

Genotyping was carried out by the iPLEX Gold Genotyping Assay. Our study comprised 420 patients with AAU and 918 healthy subjects from Han Chinese. Using the chi-square (χ2) test, alleles and genotypes were analyzed between AAU subjects and healthy controls.

All ten SNPs were successfully genotyped and four SNPs (IL10/rs1800871, IL10/rs3021094, IL10/rs2222202, IL6R/rs4845618) exhibited weak associations with AAU, as indicated by their Puncorr values. However, upon applying the Bonferroni correction, there was no significant association between AAU and the control subjects. Additionally, the haplotype analysis of the ten SNPs revealed no association with AAU.

Our findings suggested that polymorphisms of the tested ten SNPs on the IL10 and IL6R genes did not show any association with the risk of developing AAU among the Han Chinese population.