# Enoxaparin sodium combined with magnesium sulfate in the treatment of severe preeclampsia

## TL;DR

Combining enoxaparin sodium with magnesium sulfate improves outcomes for severe preeclampsia compared to using magnesium sulfate alone.

## Contribution

The study demonstrates that combining enoxaparin sodium with magnesium sulfate is more effective and safer for treating severe preeclampsia.

## Key findings

- The combination group had significantly lower D-dimer, sFlt-1, and adverse reactions compared to the single treatment group.
- The combination group showed higher PLGF levels, better Apgar scores, and longer gestation weeks.
- The treatment combination was found to be safe and effective with fewer adverse reactions.

## Abstract

To observe the treatment of severe preeclampsia in newborns with enoxaparin sodium combined with magnesium sulfate.

A retrospective analysis was conducted on the clinical data of 80 patients with severe preeclampsia admitted to Hefei Second People’s Hospital, China from January 2019 to December 2020. Treatment records showed that 40 cases received magnesium sulfate treatment (single group), and 40 cases received enoxaparin sodium combined with magnesium sulfate treatment (combination group). Levels of D-dimer, soluble fms-like tyrosine kinase 1 (sFlt-1), placental growth factor (PLGF), Apgar scores of newborns delivered before and after treatment were compared. Gestation weeks and incidence of adverse reactions were analyzed.

After treatment, levels of D-dimer, sfit-1 and adverse reactions in the combination group were significantly lower than those in the single group (P<0.05), and the level of PLGF, newborn Apgar score and length of gestation were significantly higher than those in the single group (P<0.05).

Compared to magnesium sulfate alone, the combination of enoxaparin sodium and magnesium sulfate in the treatment of pregnant women with severe preeclampsia can more effectively regulate the cytokine level of patients, improve pregnancy outcome, and improve neonatal Apgar score. The incidence of adverse reactions is low, making it a safe and efficient treatment modality.