# Verification of the utility of the gonadotropin starting dose calculator in progestin‐primed ovarian stimulation: A comparison of empirical and calculated controlled ovarian stimulation

## TL;DR

A calculator for determining gonadotropin doses in a specific fertility treatment protocol was found to be more effective than traditional methods.

## Contribution

The study shows the calculator's effectiveness in a progestin-primed ovarian stimulation protocol.

## Key findings

- The calculated group had more preovulation follicles and a higher ovarian sensitivity index.
- The calculated group showed better concordance between target and actual oocyte numbers.
- The calculator proved reliable for predicting oocyte retrieval numbers across protocols.

## Abstract

To validate the effectiveness of a gonadotropin starting dose calculator for progestin‐primed ovarian stimulation (PPOS), we conducted a study comparing the outcomes of oocyte retrieval between a group assigned gonadotropin doses via the calculator and a control group, where doses were determined by the clinician's empirical judgment.

Patients underwent controlled ovarian stimulation (COS) using the PPOS method, followed by oocyte retrieval. We assessed and compared the results of COS and oocyte retrieval in both groups. Additionally, we examined the concordance rate between the number of oocytes actually retrieved and the target number of oocytes in each group.

The calculated group demonstrated a significantly higher number of preovulation follicles and a higher ovarian sensitivity index than the control group. Furthermore, the discrepancy between the target and actual number of oocytes retrieved was notably smaller in the calculated group. The concordance rate between the target and actual number of oocytes was significantly greater in the calculated group.

The gonadotropin starting dose calculator proved to be effective within the PPOS protocol, offering a reliable method for predicting the approximate number of oocytes to be retrieved, irrespective of the COS protocol employed.

We demonstrated that the gonadotropin starting dose calculator developed based on the antagonist method is also effective for the progestin‐primed ovarian stimulation protocol. Calculated controlled ovarian stimulation (COS) was considered superior to the COS of physician's rule of thumb.