# Use of Translational Science, Continuous Glucose Monitoring in the Primary Care Setting for Management of Nesidioblastosis: A Case Report and Literature Review

## TL;DR

A 60-year-old woman with a history of gastric bypass surgery experienced hypoglycemia due to nesidioblastosis, a rare condition linked to such surgeries.

## Contribution

This case report adds to the understanding of adult-onset nesidioblastosis following Roux-en-Y gastric bypass surgery.

## Key findings

- Nesidioblastosis was diagnosed in a 60-year-old female with a history of Roux-en-Y gastric bypass.
- Hypoglycemia episodes were observed, and insulinoma was ruled out as the cause.
- The case highlights the growing association between gastric bypass surgery and nesidioblastosis in adults.

## Abstract

Nesidioblastosis is a term used to describe histologic changes in the pancreatic cell, which are defined by beta cell hypertrophy and the formation of ductoinsular complexes. It is a disease previously most extensively identified in neonates and is a rare cause of endogenous hypoglycemia in the adult population. However, with increasing numbers of gastric bypass surgeries for the management of obesity in recent years, there has been a growing number of populations with post-gastric bypass surgery-related nesidioblastosis. Here, we will present a case of a 60-year-old female with a history of Roux-en-Y gastric bypass (RYGB) surgery who initially presented with loss of consciousness and episodes of suspected hypoglycemia. Insulinoma was ruled out, supporting the diagnosis of adult onset RYGB-associated nesidioblastosis.This article was previously presented as a poster presentation at the 2023 Research Symposium, International Conference on Health Disparities, on September 8, 2023.