# Necrotizing Fasciitis of the Serratus Anterior in a Patient Treated With Infliximab and Prednisolone for Ulcerative Colitis and Rheumatoid Arthritis

## TL;DR

A patient with autoimmune diseases developed a severe bacterial infection after receiving immunosuppressive treatment.

## Contribution

The paper presents a case study of necrotizing fasciitis in a patient with immune disorders treated with infliximab and prednisolone.

## Key findings

- Necrotizing fasciitis occurred in a patient receiving immunosuppressants for ulcerative colitis and rheumatoid arthritis.
- The case highlights the time kinetics of clinical symptoms and lab data in GAS-associated NF under immunosuppression.
- The report adds to understanding of NF in immunosuppressed individuals with autoimmune conditions.

## Abstract

Necrotizing fasciitis (NF) is a rapidly progressive bacterial infection with high mortality. Invasive group A Streptococcus (GAS) infection is the leading cause of NF. Our understanding regarding clinicopathological features and pathogenesis of invasive GAS infection is expanding as the incidence of NF in healthy individuals increases. However, clinicopathological features of NF in the presence of autoimmune diseases have been poorly defined. We experienced NF in a patient treated with infliximab and prednisolone for ulcerative colitis and rheumatoid arthritis. Herein, we present time kinetics findings of clinical symptoms and laboratory data of GAS-associated NF in the presence of immunosuppressant-treated immune disorders.