# Vitiligo and Prostate Cancer Correlation

## TL;DR

This case study explores a possible connection between vitiligo and prostate cancer in a patient with both conditions.

## Contribution

The novelty lies in presenting a case where vitiligo and prostate cancer coexist, suggesting potential shared biological mechanisms.

## Key findings

- The patient's prostate cancer showed reduced prevalence and severity over five years without treatment.
- The case raises questions about possible immunological or genetic links between vitiligo and prostate cancer.
- Topical treatments for vitiligo were used, but their impact on prostate cancer was not directly studied.

## Abstract

A 72-year-old male with a history of systemic hypertension, asthma, chronic obstructive pulmonary disease (COPD), and hyperlipidemia presents with diffuse patches of cutaneous depigmentation. A shave biopsy of different regions of depigmented skin indicated vitiligo. The patient was prescribed Opzelura (ruxolitinib) 1.5% topical cream as well as tacrolimus 0.1% topical ointment for vitiligo. He also had a history of prostate cancer. A prostate biopsy revealed three sites of prostatic adenocarcinoma with a Gleason score of 6 and a Prostate Imaging-Reporting and Data System (PI-RADS) score of 2. The patient remained in active surveillance for prostate cancer without treatment, due to its low severity. A subsequent biopsy five years later revealed a decrease in prostate cancer prevalence, with cancer present in only one core and at a lower severity. The purpose of this case presentation is to discuss possible links between vitiligo and prostate cancer, as well as their shared mechanisms and pathways.