# RETRACTION: Long noncoding RNA UCA1 promotes cell growth, migration, and invasion by targeting miR‐143‐3p in oral squamous cell carcinoma

PMC · DOI: 10.1002/cam4.7338 · Cancer Medicine · 2024-05-30

## TL;DR

This retracted study claimed that a noncoding RNA promotes cancer cell growth and invasion in oral cancer by targeting a specific microRNA.

## Contribution

The paper originally proposed a novel mechanism involving UCA1 and miR-143-3p in oral squamous cell carcinoma.

## Key findings

- UCA1 promotes cell growth, migration, and invasion in oral cancer.
- UCA1 exerts its effects by targeting miR-143-3p.

## Abstract

RETRACTION: Q. Duan, M. Xu, M. Wu, X. Zhang, M. Gan, H. Jiang, “Long noncoding RNA UCA1 promotes cell growth, migration, and invasion by targeting miR‐143‐3p in oral squamous cell carcinoma,” Cancer Medicine 9, no. 9 (2020): 3115–3129, https://doi.org/10.1002/cam4.2808.

The above article, published online on March 4, 2020, in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor‐in‐Chief, Stephen Tait, and John Wiley and Sons Ltd. Following publication, concerns were raised by third parties regarding the origin of figures 7A and 7C. Unexpected similarities between an instrument in this figure and figures from other papers by unrelated author groups were found. Furthermore, duplication of a panel from figure 6D (showing MK1 cells under control conditions at 24 hours) were found within a figure from another article published elsewhere in a different scientific context. The authors were contacted and invited to comment on the concerns raised and to provide the original, unmodified figures, but did not respond. The editors have lost confidence in the data and conclusions of this study.

## Linked entities

- **Genes:** UCA1 (urothelial cancer associated 1) [NCBI Gene 652995]
- **Diseases:** oral squamous cell carcinoma (MONDO:0004958)

## Full-text entities

- **Genes:** UCA1 (urothelial cancer associated 1) [NCBI Gene 652995] {aka CUDR, LINC00178, NCRNA00178, UCAT1, onco-lncRNA-36}
- **Diseases:** oral squamous cell carcinoma (MESH:D000077195), Cancer (MESH:D009369)
- **Cell lines:** MK1 — Macaca fascicularis (Crab-eating macaque), Spontaneously immortalized cell line (CVCL_3631)

## Full text

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Source: https://tomesphere.com/paper/PMC11137348