# Challenges and proposed solutions to conducting Alzheimer’s disease psychosis trials

## TL;DR

This paper outlines challenges in Alzheimer's disease psychosis clinical trials and suggests solutions to improve treatment development.

## Contribution

The paper proposes seven specific solutions to address challenges in Alzheimer’s disease psychosis trials.

## Key findings

- Placebo response variability is a major challenge in ADP trials.
- Proposed solutions include updated diagnostic criteria and technology for symptom assessment.
- Feasible biomarkers and statistical approaches are recommended to improve trial outcomes.

## Abstract

Alzheimer’s disease psychosis (ADP) produces a significant burden for patients and their care partners, but at present there are no approved treatments for ADP. The lack of approved treatments may be due to the challenges of conducting clinical trials for this disease. This perspective article discusses distinct challenges and proposed solutions of conducting ADP trials involving seven key areas: (1) methods to reduce the variable and sometimes high rates of placebo response that occur for treatments of neuropsychiatric symptoms; (2) the use of combined or updated criteria that provide a precise, consensus definition of ADP; (3) the use of eligibility criteria to help recruit individuals representative of the larger ADP population and overcome the difficulty of recruiting patients with moderate-to-severe ADP; (4) consideration of multiple perspectives and implementation of technology to reduce the variability in the administration and scoring of neuropsychiatric symptom assessments; (5) the use of clinically appropriate, a priori–defined severity thresholds and responder cutoffs; (6) the use of statistical approaches that address absolute effect sizes and a three-tier approach to address the fluctuation of neuropsychiatric symptoms; and (7) the implementation of feasible diagnostic and target-engagement biomarkers as they become available. The goal of these proposed solutions is to improve the evaluation of potential ADP therapies, within the context of randomized, placebo-controlled trials with clinically meaningful endpoints and sustained treatment responses.