# A Rare Presentation of Systemic Lupus Erythematosus in a Patient With Fever of Unknown Origin

## TL;DR

A 23-year-old man with unexplained fever was diagnosed with a rare case of systemic lupus erythematosus, highlighting the need to consider lupus in similar cases.

## Contribution

Highlights a rare presentation of lupus as fever of unknown origin and emphasizes its inclusion in differential diagnosis.

## Key findings

- Systemic lupus erythematosus was diagnosed in a male with fever of unknown origin.
- Timely diagnosis and intervention are crucial for improving outcomes in lupus cases.
- Lupus should be considered in the differential diagnosis of fever of unknown origin in young males.

## Abstract

This case presents a 23-year-old male with a rare presentation of lupus as fever of unknown origin (FUO). The patient's clinical symptoms, examination findings, and laboratory results painted a complex picture that necessitated considering macrophage activation syndrome and adult-onset Still's disease but ultimately led to the diagnosis of systemic lupus erythematosus. The case emphasizes the importance of including lupus in the differential diagnosis of FUO given the associated risks and higher mortality rates in this demographic, especially in males. Understanding lupus prevalence and classification criteria aids in diagnosis, highlighting the importance of a systematic approach for FUO and emphasizing timely intervention for improved patient outcomes.