Nonthermal biocompatible plasma in stimulating osteogenic differentiation by targeting p38/ FOXO1 and PI3K/AKT pathways in hBMSCs
Khadija Akter, Youngsun Kim, Eun Ha Choi, Ihn Han
TL;DR
Nonthermal plasma boosts bone cell development in human stem cells by activating specific signaling pathways, offering potential for treating osteoporosis.
Contribution
This study reveals how nonthermal plasma promotes bone cell differentiation via p38/FOXO1 and PI3K/AKT pathways in hBMSCs.
Findings
Nonthermal plasma enhances osteogenic differentiation in hBMSCs.
NBP activates the p38/FOXO1 pathway and the PI3K/AKT signaling cascade.
BMP signaling is upregulated, contributing to bone cell development.
Abstract
Osteoporosis is manifested by decreased bone density and deterioration of bone architecture, increasing the risk of bone fractures Human bone marrow mesenchymal stem cells (hBMSCs)-based tissue engineering serves as a crucial technique for regenerating lost bone and preventing osteoporosis. Non-thermal biocompatible plasma (NBP) is a potential new therapeutic approach employed in several biomedical applications, including regenerative medicine. NBP affects bone remodeling; however, its role in the regulation of osteogenic differentiation in hBMSCs remains largely unexplored. This study aimed to explore the efficiency of NBP in promoting osteogenic differentiation, and the molecular pathways through which these responses occurred in hBMSCs. We found that NBP facilitated osteogenic differentiation through the upregulation of the bone morphogenic protein signal (BMPs) cascade, which in…
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Taxonomy
TopicsReligious and Theological Studies · Comparative constitutional jurisprudence studies · Theology and Canon Law Studies