# Double Digest: A Rare Case Report of Amphicrine Gastric Carcinoma Co-occurring With Papillary Thyroid Carcinoma

## TL;DR

A rare case of two cancers, amphicrine gastric carcinoma and papillary thyroid carcinoma, occurring simultaneously in a 55-year-old woman is reported.

## Contribution

This is the first documented case of amphicrine carcinoma co-occurring with papillary thyroid carcinoma.

## Key findings

- The patient was diagnosed with both amphicrine carcinoma and papillary thyroid carcinoma during a pre-surgery evaluation.
- Amphicrine carcinoma is a rare gastric cancer with both endocrine and epithelial cell features.
- This case highlights the possibility of multiple rare cancers occurring simultaneously.

## Abstract

With improved cancer treatments and patient lifespans, the incidence of a second cancer diagnosis in a person’s lifetime is increasing. While dual cancer diagnoses during one’s lifetime are becoming more common, diagnosis with two separate cancers simultaneously is less so. In this report we present a 55-year-old obese woman with a history of chronic lymphocytic thyroiditis and a non-specific family history of thyroid cancer who received synchronous diagnoses of amphicrine carcinoma (AC) and papillary thyroid carcinoma (PTC) during work-up for bariatric surgery. AC is a very rare form of gastric cancer characterized by the presence of both endocrine and epithelial cell components within the same cell with only a few case reports in the literature. This is the first case report to present the co-occurrence of AC with PTC.