# Marfan Syndrome Associated With Acute Myocardial Infarction in the First Trimester of Pregnancy

## TL;DR

A 30-year-old pregnant woman with Marfan syndrome experienced a rare heart attack during her first trimester, marking the first reported case of this condition during early pregnancy.

## Contribution

This paper presents the first documented case of acute myocardial infarction in a Marfan syndrome patient during the first trimester of pregnancy.

## Key findings

- A 30-year-old woman with Marfan syndrome had an acute myocardial infarction at 12 weeks of gestation.
- The patient had a history of ascending aorta aneurysm and aortic valve repair.
- This case highlights the rare but severe cardiovascular risks in pregnant Marfan syndrome patients.

## Abstract

Marfan syndrome (MFS) is a rare hereditary connective tissue disorder with autosomal dominant inheritance associated with an increased risk of cardiovascular complications due to connective tissue fragility. Acute myocardial infarction during pregnancy is also a rare event associated with poor maternal and fetal outcomes. Herein, we report a case of a 30-year-old pregnant woman with a known history of MFS. The patient had been treated surgically for an ascending aorta aneurysm and mechanical prosthetic aortic valve repair. She presented at 12 weeks of gestation with severe chest pain, which proved to be acute myocardial infarction. This is believed to be the first case of this complex medical condition presented in the first trimester of pregnancy.