# Oral Immunotherapy With Extensively Hydrolyzed Milk for a 12-Year-Old Child With Persistent, Severe Cow’s Milk Allergy

## TL;DR

A 12-year-old girl with a severe milk allergy successfully underwent oral immunotherapy using hydrolyzed milk, allowing her to tolerate regular milk after three and a half years.

## Contribution

This case presents an alternative OIT approach using extensively hydrolyzed milk for persistent cow's milk allergy.

## Key findings

- The patient could safely consume 300 mL of unhydrolyzed cow's milk after three and a half years of treatment.
- The patient consistently consumed over 200 mL of milk without symptoms for six months.
- OIT with hydrolyzed milk may offer a safer alternative for treating persistent cow's milk allergy.

## Abstract

A 12-year-old girl with severe cow's milk allergy (CMA) was able to safely consume 300 mL of unhydrolyzed cow's milk after three and a half years of oral immunotherapy (OIT) with extensively hydrolyzed milk. The treatment consisted of gradually increasing the intake of hydrolyzed and partially hydrolyzed milk and reintroducing cow's milk. Despite some allergic reactions during treatment, the patient was able to consume more than 200 ml of milk consistently for more than six months without recurrence of symptoms. This case suggests the possibility of an alternative treatment for persistent CMA: not only OIT with cow's milk alone but also a safer introduction to treatment with extensively hydrolyzed formulas.