# Histiocytoid Sweet’s Syndrome in the Setting of Myelodysplastic Syndrome

## TL;DR

This case report describes a rare skin condition in a patient with a blood disorder and a history of infections.

## Contribution

The paper presents a unique case of histiocytoid Sweet’s syndrome in a patient with myelodysplastic syndrome and prior infections.

## Key findings

- Histiocytoid Sweet’s syndrome was diagnosed in a patient with myelodysplastic syndrome.
- The patient had a history of Mycobacterium avium complex infection and latent tuberculosis.
- Treatment was tailored to the patient's immunocompromised state.

## Abstract

Acute febrile neutrophilic dermatosis, or Sweet’s syndrome, is characterized by tender, edematous papules and plaques, favoring the upper extremities and the head and neck regions. The classic variant of Sweet’s syndrome involves a predominantly neutrophilic dermal infiltrate on histopathology. However, histiocytoid Sweet’s syndrome has been noted to have a primary histiocytoid mononuclear infiltrate and is typically found in patients with malignancies such as myelodysplasia. This case report discusses the treatment of histiocytoid Sweet’s syndrome in an immunocompromised patient with a recent history of Mycobacterium avium complex infection and latent tuberculosis in the setting of myelodysplastic syndrome.