# Gender Differences in the Evaluation and Management of New Acute CHF Due to ATTRwt Cardiac Amyloidosis

## TL;DR

This paper explores how gender differences affect the diagnosis and treatment of a type of heart disease caused by protein buildup in the heart.

## Contribution

The study highlights the gender disparity in diagnosing and managing ATTRwt cardiac amyloidosis and suggests earlier detection in females.

## Key findings

- ATTRwt cardiac amyloidosis is reported to affect males more than females.
- Older patients diagnosed with ATTRwt are more likely to be female.
- Earlier diagnosis in females could lead to better treatment outcomes.

## Abstract

Cardiac amyloidosis can be grouped into two main categories: immunoglobulin light chain (AL) and transthyretin (hATTR or hereditary and ATTRwt or wild type). Cardiac infiltration of misfolded proteins can lead to significant infiltrative processes and subsequent heart failure. Diagnosis of ATTRwt heavily relies on clinical suspicion, as it typically appears later in life and is limited to the heart. It is routinely reported that ATTRwt significantly affects males more than females; however, older patients diagnosed with ATTRwt and those diagnosed at autopsy are significantly more likely to be female. Earlier, a more precise diagnosis in females could detect disease at an earlier stage and expedite treatment.