Fibrolamellar Carcinoma: A Rare Liver Neoplasm
Elily D Apumayta, Aaron Kahlam, Eloy F Ruiz
TL;DR
This paper presents five cases of fibrolamellar carcinoma, a rare liver cancer in young patients, focusing on their treatment and outcomes.
Contribution
The study contributes a case series highlighting clinical features and recurrence rates after liver resection in young fibrolamellar carcinoma patients.
Findings
Median age of diagnosis was 24 years with nonspecific symptoms in otherwise healthy patients.
60% of patients experienced recurrence within one year after hemihepatectomy.
Classical imaging and histological features were observed in all cases.
Abstract
Fibrolamellar carcinoma is a rare liver tumor, with most cases arising in people younger than 40 years of age. We present a case series of five patients with histological confirmation of fibrolamellar carcinoma who had liver resection as the primary treatment. The median age of diagnosis was 24 years with nonspecific clinical manifestations in otherwise healthy patients. Alpha-fetoprotein levels were widely variable. Patients had classical imaging, macroscopic, and microscopic findings. Most of our patients underwent a hemihepatectomy and 60% recurred after the first year.
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Taxonomy
TopicsHepatocellular Carcinoma Treatment and Prognosis · Cholangiocarcinoma and Gallbladder Cancer Studies · Viral-associated cancers and disorders