# Correlation analysis between serum total IgE and FeNO and idiosyncratic reaction in bronchiolitis

## TL;DR

This study examines how IgE and FeNO levels relate to bronchiolitis severity and idiosyncratic reactions in children.

## Contribution

The study reveals the correlation between IgE and FeNO with bronchiolitis severity but finds limited diagnostic value for idiosyncratic bronchiolitis.

## Key findings

- FeNO levels are lower in bronchiolitis children compared to healthy children.
- Serum total IgE increases while FeNO decreases as bronchiolitis worsens.
- IgE and FeNO have limited diagnostic value for idiosyncratic bronchiolitis with AUC less than 0.7.

## Abstract

•FeNO in bronchiolitis children was lower than that in healthy children.•Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children.•Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgEand FeNO were not the risk factors for idiosyncratic bronchiolitis.•Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

FeNO in bronchiolitis children was lower than that in healthy children.

Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children.

Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgEand FeNO were not the risk factors for idiosyncratic bronchiolitis.

Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

This article focused on the correlation between the changes of serum total Immunoglobulin E (IgE) and Fractional exhaled Nitric Oxide (FeNO) and idiosyncratic reactions in children with bronchiolitis.

One hundred children with bronchiolitis and fifty healthy children were enrolled. Serum total IgE and FeNO were assessed, and the diagnostic value for bronchiolitis and the correlation with the severity of bronchiolitis were analyzed. Bronchiolitis children were divided into idiosyncratic + bronchiolitis and non-idiosyncratic + bronchiolitis groups, the relationship between serum total IgE and FeNO and idiosyncratic reaction was determined, and the diagnostic value of serum total IgE and FeNO for idiosyncratic bronchiolitis was examined.

FeNO in bronchiolitis children was lower than that in healthy children but there was no significant difference in serum total IgE levels between the two populations. Serum total IgE increased while FeNO decreased with the aggravation of bronchiolitis in bronchiolitis children. The serum total IgE was positively correlated while FeNO was negatively correlated with the severity of bronchiolitis. Serum total IgE was higher in children with idiosyncratic bronchiolitis, but serum total IgE and FeNO were not the risk factors for idiosyncratic bronchiolitis; Area Under the Curve (AUC) of serum total IgE and FeNO for the diagnosis of idiosyncratic bronchiolitis was less than 0.7.

Serum total IgE and FeNO in children with bronchiolitis are related to disease severity and idiosyncratic reaction. FeNO has a diagnostic value for bronchiolitis, but not for idiosyncratic bronchiolitis.