Metal–Organic Framework-Capped Gold Nanorod Hybrids for Combinatorial Cancer Therapy
Chong Zhao, Hongxiang Liu, Sijun Huang, Yi Guo, Li Xu
TL;DR
This paper introduces a new hybrid nanomaterial that combines gold nanorods and metal-organic frameworks to improve cancer treatment by combining heat therapy, enzyme-like activity, and drug delivery.
Contribution
The novel contribution is the synthesis of metal–organic framework-capped gold nanorod hybrids for combinatorial cancer therapy.
Findings
The hybrids can kill tumor cells by locally increasing temperature through photothermal effects.
They exhibit peroxidase-like activity, disrupting oxidative balance in vitro.
They enable effective drug delivery, reducing toxicity and side effects of chemotherapy.
Abstract
Recently, nanomaterials have attracted extensive attention in cancer-targeting therapy and as drug delivery vehicles owing to their unique surface and size properties. Multifunctional combinations of nanomaterials have become a research hotspot as researchers aim to provide a full understanding of their nanomaterial characteristics. In this study, metal–organic framework-capped gold nanorod hybrids were synthesized. Our research explored their ability to kill tumor cells by locally increasing the temperature via photothermal conclusion. The specific peroxidase-like activity endows the hybrids with the ability to disrupt the oxidative balance in vitro. Simultaneously, chemotherapeutic drugs are administered and delivered by loading and transportation for effective combinatorial cancer treatment, thereby enhancing the curative effect and reducing the unpredictable toxicity and side…
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Taxonomy
TopicsAdvanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications