# Intraneural Melanoma Identified With MART-1 Immunostaining in Mohs Micrographic Surgery

## TL;DR

This paper describes a case where melanoma invading nerves was successfully detected using a specific staining technique during a precise surgical procedure.

## Contribution

The case highlights the effectiveness of MART-1 immunostaining in identifying neurotropic melanoma during Mohs surgery.

## Key findings

- Neurotropic melanoma was identified using MART-1 immunostaining during Mohs surgery.
- The tumor was confirmed with permanent sectioning after initial detection.
- The method helped avoid local recurrence by accurately identifying tumor margins.

## Abstract

Mohs micrographic surgery (MMS) utilizing melanoma antigen recognized by T-cells (MART-1) immunostaining is an increasingly common method of treatment for minimally invasive melanoma in anatomically constrained areas such as the face, ears, or acral sites. Neurotropic melanoma, also known as neurotrophism in melanoma, refers to the invasion of melanoma cells into the nerves. As such, these tumors can extend well beyond anticipated clinical tumor margins which can increase the risk of local recurrence. Here, we present a case of neurotropic melanoma successfully identified during MMS using MART-1 immunostaining, which was then confirmed with permanent sectioning.