# Revolution in Cancer Treatment: How Are Intelligently Designed Nanostructures Changing the Game?

## TL;DR

This paper explores how smart nanostructures are transforming cancer treatment by improving drug delivery and precision, especially for hard-to-treat cancers like head and neck cancer.

## Contribution

The paper introduces new insights into the design and application of nanostructures for personalized cancer therapy.

## Key findings

- Nanostructures can be tailored to overcome biological barriers and enhance drug delivery.
- Specialized nanostructures show promise in treating aggressive cancers like head and neck cancer.
- Current trends and future directions highlight the potential for more precise and personalized cancer treatments.

## Abstract

Nanoparticles (NPs) are extremely important tools to overcome the limitations imposed by therapeutic agents and effectively overcome biological barriers. Smart designed/tuned nanostructures can be extremely effective for cancer treatment. The selection and design of nanostructures and the adjustment of size and surface properties are extremely important, especially for some precision treatments and drug delivery (DD). By designing specific methods, an important era can be opened in the biomedical field for personalized and precise treatment. Here, we focus on advances in the selection and design of nanostructures, as well as on how the structure and shape, size, charge, and surface properties of nanostructures in biological fluids (BFs) can be affected. We discussed the applications of specialized nanostructures in the therapy of head and neck cancer (HNC), which is a difficult and aggressive type of cancer to treat, to give an impetus for novel treatment approaches in this field. We also comprehensively touched on the shortcomings, current trends, and future perspectives when using nanostructures in the treatment of cancer.