# Advanced Antimicrobial and Anti-Infective Strategies to Manage Peri-Implant Infection: A Narrative Review

## TL;DR

This paper reviews new strategies to prevent implant infections without relying heavily on antibiotics.

## Contribution

The paper highlights novel biomaterial and immune-based strategies to reduce systemic antibiotic use in managing peri-implant infections.

## Key findings

- Modifying dental implant surfaces can help prevent peri-implant infections.
- Regulating early immune responses is a promising approach to infection prevention.
- Advanced biomaterials may reduce the need for systemic antibiotics and their side effects.

## Abstract

Despite reductions in bacterial infection and enhanced success rate, the widespread use of systemic antibiotic prophylaxis in implant dentistry is controversial. This use has contributed to the growing problem of antimicrobial resistance, along with creating significant health and economic burdens. The basic mechanisms that cause implant infection can be targeted by new prevention and treatment methods which can also lead to the reduction of systemic antibiotic exposure and its associated adverse effects. This review aims to summarize advanced biomaterial strategies applied to implant components based on anti-pathogenic mechanisms and immune balance mechanisms. It emphasizes that modifying the dental implant surface and regulating the early immune response are promising strategies, which may further prevent or slow the development of peri-implant infection, and subsequent failure.